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diagnosis hyperkalemia algorithm causes diuretics high hypokalemia medications binder classes conversion diuresis druginduced excretion kbinder loop management pathophysiology patiromer renal
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Increased EC shift of K ... • Exogenous (KCL ... #hyperkalemia #differential ... pathophysiology #pharmacology ... #potassium #medications
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... • NSAIDs • ACE ... • Recent IV potassium ... Beta blockers • Antibiotics ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... • NSAIDs • ACE ... • Recent IV potassium ... Beta blockers • Antibiotics ... #high #nephrology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine Urine K+
the basis of the potassium-to-creatinine ... • Low Urine Cl ... hypokalemia #urine #potassium ... #differential # ... algorithm #diagnosis #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
NSAIDs, β-blockers, Antibiotics ... Stabilization Treatments ... Ca-gluconate or 1g CaCl ... Redistribution Treatments ... #potassium #nephrology
Diuretics - Pharmacology Thiazides diuretics: • Inhibit Na+ Cl- cotransporter in distal tubule • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... • Inhibit Na+ Cl ... • Inhibit Na+K+ ... Piretanide Potassium ... #nephrology #conversion
Veltassa (Patiromer) MECHANISM: Potassium Binder INDICATION: Treatment of Hyperkalemia FORMULATION: Powder for oral suspension DOSING: 8.4
) MECHANISM: Potassium ... INDICATION: Treatment ... needed, based on K ... ACE inhibitors, ... #Hyperkalemia #Pharmacology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
Inhibitors of Na+K+ ... 2Cl- Symport (Loop ... Tolvaptan) • Treatment ... Excretion #Diuresis #Nephrology ... #Pharmacology #
Pragmatic diagnostic algorithm for hypokalemia. ***Typical presentations: • Vomiting: urine Na/Cl > 1.6, low urine
1.6, low urine Cl ... Tubulopathy: urine K/ ... correcting serum potassium ... hypokalemia #diagnosis #differential ... #algorithm #nephrology
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