9 results
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
Potassium Excretion ... Aldosterone Release: ACE ... Decreased Na, K-ATPase ... Pathophysiology #Pharmacology ... #Renal
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... • NSAIDs • ACE ... • Recent IV potassium ... Beta blockers • Antibiotics ... #hyperkalemia #differential
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... • NSAIDs • ACE ... • Recent IV potassium ... Beta blockers • Antibiotics ... #hyperkalemia #differential
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Increased EC shift of K ... • Exogenous (KCL ... #hyperkalemia #differential ... pathophysiology #pharmacology ... #potassium #medications
Emergent Hyperkalemia Treatment Algorithm
ECG changes, weakness, K+ >6.5 Or renal insufficiency with K >5.5 with cellular
Emergent Hyperkalemia Treatment ... >6.5 Or renal insufficiency ... as a standalone treatment ... Remove potassium ... offending agent (ACE-I
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
NSAIDs, β-blockers, Antibiotics ... - Renal Failure ... 15 suggests ↓ renal ... Ca-gluconate or 1g CaCl ... #potassium #nephrology
Veltassa (Patiromer) 
MECHANISM: Potassium Binder 
INDICATION: Treatment of Hyperkalemia 
FORMULATION: Powder for oral suspension 
DOSING: 8.4
) MECHANISM: Potassium ... INDICATION: Treatment ... needed, based on K ... ACE inhibitors, ... #Hyperkalemia #Pharmacology
The crusade against “Ab”Normal Saline continues.  This is a non-physiologic fluid that can harm our
is dominated by K+ ... exchange for H+, K+ ... as a too much K+ ... management #diagnosis #treatment ... #pharmacology #
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Agents Regulating Renal ... Inhibitors of Na+K+ ... 2Cl- Symport (Loop ... Tolvaptan) • Treatment ... Diuresis #Nephrology #Pharmacology