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diagnosis hematology management oncology algorithm allergy anemia cardiology cd4 classification differentiation effusion eosinophilia extravascular gap globulin hemolysis hemolytic hodgkins hyperviscosity
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... Score • CML -> AML ... : Blast crises ... smear: Blasts APML ... • Tumor lysis syndrome
Eosinophilia - Differential Diagnosis Algorithm Idiopathic Eosinophilia Primary Eosinophilia: • Primary hypereosinophilic syndrome • Eosinophilic Leukemia • MPN/MDS
Eosinophilia - Differential ... Diagnosis Algorithm Idiopathic ... ), Heme malig (AML ... CML, T-cell leuk/lymphoma ... , B-cell lymphomas
Causes of Pericardial Effusion - Differential Diagnosis Infectious: • Viral: Enterovirus, Herpesvirus, Adenovirus, Parvovirus • Bacterial: Mycobacterium
Causes of Pericardial ... Effusion - Differential ... Non-Infectious: • Rheumatologic ... Malignant - Primary: Lymphoma ... , Dissection, Idiopathic
Hyperviscosity Syndrome - Causes and Treatment - Waldenstrom macroglobulinemia (most common) / Plasmapheresis - Multiple
Hyperviscosity Syndrome ... - Causes and Treatment ... hyperleukocytosis (AML ... #Causes #Differential ... #Diagnosis #Treatment
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... Incidence: common in APL ... Triggers: ATRA treatment ... initiation • Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... e.g. lupus, CLL, lymphoma ... , idiopathic) ... #differential #
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
transformation to AML ... Cell Leukemia • Idiopathic ... Significance (ICUS) • Idiopathic ... blood count with differential ... progression to AML
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... (90-95% of cases ... Immunohistochemical studies (to differentiate ... Treatment • Early ... classification #hematology
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
Idiopathic CD4 Lymphopenia ... chemotherapy) • Genetic syndromes ... Unc119) • Heme (lymphoma ... #Differential # ... Causes #lymphocytopenia
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Amyloidosis • Lymphoma ... changes (POEMS syndrome ... Castleman disease • AL ... : Lymphoma, Leukemia ... Gap #ProteinGap #differential
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