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differential causes nephrology management review algorithm hypokalemia table high treatment drug hematology induced mnemonic oncology pathophysiology renal syndrome comparison druginduced
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... MunerMohamed1 #hyperkalemia ... #differential #diagnosis ... pathophysiology #pharmacology ... #potassium #medications
Causes of Hyperkalemia Hyperkalemia is caused by excess potassium intake, impaired potassium excretion, or transcellular shifts. The
caused by excess potassium ... intake, impaired potassium ... renal function, medication ... adapt to excess potassium ... dysfunction is common #Diagnosis
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 Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... • NSAIDs • ACE ... Beta blockers • Antibiotics ... Medications 2. ... #causes #potassium
Drugs that Impair Renal Potassium Excretion Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine Decreased Aldosterone Synthesis: Heparin,
that Impair Renal Potassium ... Aldosterone Release: ACE ... happypillsrx/ #Hyperkalemia ... Pathophysiology #Pharmacology ... #Impaired #Potassium
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... • NSAIDs • ACE ... • Recent IV potassium ... Beta blockers • Antibiotics ... Medications 2.
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... Agents to Treat Hyperkalemia ... to moderate); hypokalemia ... of aspiration #Potassium ... #medications #pharmacology
Constipation - Differential Diagnosis Algorithm Diet/Lifestyle • Fibre • Calories • Fluid • Exercise • Psychosocial Medications •
- Differential Diagnosis ... Psychosocial Medications ... Neurally Active Medications ... Aluminum, Calcium, Potassium ... • Hypercalcemia
Linezolid (Zyvox) (PO and IV) - Antibiotics Class Overview Mechanism: Oxazolidinone class –unique ribosomal inhibitor (acts on
(PO and IV) - Antibiotics ... Class Overview ... Spectrum: covers all ... infections #Pharmacology ... #Antibiotics #Review
Hypokalemia Differential Diagnosis Algorithm Hypertensive: • High Al, Low R - Primary aldosteronism • High Al, High
Hypokalemia Differential ... Diagnosis Algorithm ... Gitelman's syndrome #Hypokalemia ... #Differential #Diagnosis ... #causes #low #potassium
Hypokalemia - Differential Diagnosis Algorithm Transcellular Shift: • Alkalosis • ↑ beta-2 adrenergic simulation • Erythropoiesis
Hypokalemia - Differential ... Diagnosis Algorithm ... Thyrotoxicosis Medications ... #Differential #Diagnosis ... nephrology #low #potassium
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