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diagnosis causes symptoms algorithm gh management neurology pituitary potassium syndrome workup 21hydroxylasedeficiency 21ohd benzodiazepine bzd calcium cardiology color comatose ddxof
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... MunerMohamed1 #hyperkalemia ... #differential # ... diagnosis #pathophysiology ... #pharmacology #
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... metabolic abn #GrowthHormone ... #FeedbackLoop #endocrinology ... #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... fraction • HTN #GrowthHormone ... Overproduction #diagnosis #signs ... #symptoms #endocrinology ... #pathophysiology
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Hyperuricemia - Differential ... Sarcoidosis • Hypercalcemia ... drugs • ACE ... Hyperuricemia #Differential ... Diagnosis #Algorithm #endocrinology
Drugs that Impair Renal Potassium Excretion Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine Decreased Aldosterone Synthesis: Heparin,
Aldosterone Release: ACE ... happypillsrx/ #Hyperkalemia ... #Pathophysiology ... #Pharmacology #
Hypercalcemia Evaluation 1) Clinical clues - Is the patient symptomatic? - Family history? - Have you done
Hypercalcemia Evaluation ... Vit D • If all ... BrighamChiefs #Hypercalcemia ... #workup #differential ... #diagnosis #endocrinology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
wasting crisis & hyperkalemia ... Signs/Symptoms/Complications ... : • Hyperkalemia ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology
Maculopapular - Diagnostic Algorithm Pathophysiology: - Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Diagnostic Algorithm Pathophysiology ... : - Catch-all term ... - Pathophysiology ... Ill-appearing, vital sign ... Targetoid #Algorithm #Differential
Causes of Secondary Hypertension - Workup and Differential Diagnosis Approach (when evaluation should be done): 1. Severe or
Hypertension - Workup and Differential ... hypertension and signs ... disorders including hypokalemia ... renal bruit or signs ... Vasculitis • Endocrinologic
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... have fever - ACS ... WBC >100k, + lab signs ... Lysis Syndrome: • Pathophysiology ... hydration - Hyperkalemia
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