19 results
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... only curative treatment ... #Management #treatment ... #hematology #oncology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Disorders Testing Algorithm ... evaluation or workup ... 1,500 cells/µL Workup ... glucocorticoid treatment ... #Differential #diagnosis
Suggested diagnostic approach to a patient with exudative ascites. Low ascitic fluid protein should direct practitioners
out nephrotic syndrome ... as a cause for ... Although nonhepatic causes ... only about 15% of all ... #workup #algorithm
Short Stature - Differential Diagnosis Algorithm
Normal Variant, Normal Puberty Onset (BA = CA)
 • Familial Short
- Differential Diagnosis ... Algorithm Normal ... Panhypopituitarism Treatment ... #Algorithm #endocrinology ... #causes #pediatrics
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... for workup, including ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... #Algorithm #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Out Secondary Causes ... Workup: • Complete ... #diagnosis #hematology ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
: Blast crises ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... Triggers: ATRA treatment ... Renal Failure Treatment ... #oncology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... have fever - ACS ... organ damage • Treatment ... #TLS #diagnosis ... #management #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
phenomenon CLL Diagnosis ... microglobulin Treatment ... • Richter’s Syndrome ... #workup #oncology ... #hematology