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management diagnosis differential pharmacology hematology nephrology causes indications algorithm tls cancer cardiology dermatology table classification criticalcare gastroenterology hyperkalemia leukemia neurology
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... malignancies Treatments ... wandering_er #Tumor #Lysis ... #Syndrome #TLS ... #oncology #management
Tumor lysis syndrome (TLS) - Pathophysiology: → Massive tumor cell lysis → Release of large amounts of K+,
Tumor lysis syndrome ... Massive tumor cell lysis ... cytotoxic therapy of ALL ... , AML, NHL → AKI ... #TumorLysis #syndrome
Tumor Lysis Syndrome - Workup and Management Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... of the above Treatment ... #TLS #Tumor #Lysis ... #Syndrome #diagnosis ... #management #oncology
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
Classification of Tumor Lysis ... Syndrome (TLS) ... and Treatment of ... #TumorLysis #Syndrome ... diagnosis #management #oncology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Syndrome Leukostasis ... have fever - ACS ... organ damage • Treatment ... Low calcium • Treatment ... - Hyperkalemia treatment
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
malignancies Treatment ... Capillary leak syndrome ... Interleukin-2) • Tumor lysis ... syndrome • Proximal ... #AKI #Cancer #Oncology
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Oncologic Emergencies ... Hyperviscosity Syndrome ... Superior Vena Cava Syndrome ... EMERGENCIES: Tumor Lysis ... Syndrome: • Azotemia
Tumor Lysis Syndrome (TLS) Pathophysiology Culprits: ALL, Burkitt, SCLC Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... Burkitt, SCLC Cells all ... above #Tumor #Lysis ... #Syndrome #TLS ... Pathophysiology #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... develop leukostasis syndrome ... & DIC • Tumor lysis ... syndrome: Develops ... Leukemia #Hematology #Oncology
Medications Used in Hypertensive Emergencies Vasodilators: Hydralazine, Nitroglycerin, Sodium nitroprusside Calcium Channel Blockers: Clevidipine, Nicardipine ß-Blockers: Esmolol, Labetalol,
Medications Used ... Labetalol, Metoprolol ACE ... #Hypertension #Medications ... #Management #Treatment
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