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Characteristics of Serotonin Syndrome and Other Hyperthermic Syndromes Serotonin Syndrome - SSRIs, second-generation antidepressants, MAOIs, linezolid,
Characteristics of Serotonin Syndrome ... Other Hyperthermic Syndromes ... Serotonin Syndrome ... diarrhea, mydriasis, agitation ... #Hyperthermic #Syndromes
Serotonin Syndrome - THINK: FAST - FAST onset - FAST movements (agitation, akathisia, HYPERreflexia) - FAST
Serotonin Syndrome ... FAST movements (agitation ... Neuroleptic Malignant Syndrome ... NeurolepticMalignant #Syndrome
When trying to differentiate between the two conditions think “FAST” with Serotonin Syndrome and “SLOW” with
with Serotonin Syndrome ... Neuroleptic Malignant Syndrome ... Serotonin Syndrome ... FAST movements (agitation ... Neuroleptic Malignant Syndrome
Serotonin Syndrome - Rapid onset - Combination of 2+ serotonin agonists Mental status changes:
Serotonin Syndrome ... changes: - Agitation ... #Serotonin #Syndrome
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects • Serotonin Syndrome: - Autonomic Hyperactivity:
• Serotonin Syndrome ... Cognitive Changes: Agitation ... SSRI Withdrawal Syndrome
Clinical Manifestations of Serotonin Syndrome • Ophthalmologic: Mydriasis, Ocular clonus (slow horizontal movements) • Gastrointestinal: Diarrhea,
Manifestations of Serotonin Syndrome ... flushing • CNS: Agitation ... ucsdim #Serotonin #Syndrome
Posterior Reversible Encephalopathy Syndrome (PRES) - Diagnosis Clinical Features: • Altered mental status (Either lethargy, confusion, or
Encephalopathy Syndrome ... confusion, or agitation ... Encephalopathy #Syndrome
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting Serotonin Syndrome - Potentially Life
Vomiting Serotonin Syndrome ... Cognitive Changes: Agitation
Hypertension and Altered Mental Status (AMS) - Differential Diagnosis Framework Hypertension: • Hypertensive emergency • Hypertensive encephalopathy
• Cushing’s syndrome ... NCSE • Delirium/agitation ... • Serotonin syndrome
Management of Serotonin Syndrome Identify and stop all serotoninergic medications • Avoid inadvertent Rx of serotoninergic meds
Management of Serotonin Syndrome ... Benzodiazepines for agitation ... ucsdim #Serotonin #Syndrome
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