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Antifungal Polyenes - Amphoterecin B, Abelcet, Ambisome - Antibiotics Class Overview Mechanism: binds ergosterol in membrane and
Antifungal Polyenes ... Amphoterecin B, Abelcet, Ambisome ... severe fungal infections ... 2nd-line for candida infections ... Overview #Polyenes #Antifungal
Tinea Versicolor (Pityriasis versicolor) NOT a dermatophyte infection Caused by saprophytic, lipid-dependent yeasts Clinical •
a dermatophyte infection ... Management • Topical antifungals ... • Oral antifungal
Spectrum of activity for systemic antifungal agents Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
activity for systemic antifungal ... agents Antifungals ... .2015.10.012 #Antifungal
Histoplasmosis - Histoplasma capsulatum Found in Spelunkers. Caves. Bat and Bird droppings Distribution: Mississippi and Ohio River
• Disseminated infection ... immunocompromised • Primary infection ... Flu-like • Chronic infection ... Treatment: • Antifungal
Antifungal Coverage Activity Antibiogram Spectrum of action of systemic antifungal agents. Solid blocks represent species in
Antifungal Coverage ... action of systemic antifungal ... species in which the antifungal ... PMC3146381/ #Antifungal
Common toxicities of antifungal agents. CNS = central nervous system; 5-FC = flucytosine; GI = gastrointestinal;
toxicities of antifungal ... #antifungal #toxicities
IDSA Aspergillosis Treatment • Invasive pulmonary aspergillosis (IPA) • CNS aspergillosis • Cardiac Aspergillus infection •
Cardiac Aspergillus infection ... • Aspergillus infections ... of eye Infectious
Invasive Candidiasis (IC) Diagnosis: Culture: • Gold standard, but Slow (~2-3 days), 50% sensitivity • Blood Sample •
Tests Conduct antifungal ... CVC Removal • Infectious ... Candidiasis #IC #antifungal
Antifungal Echinocandins - Antibiotics Class Overview Mechanism: Inhibit glucan synthesis in fungal cell wall by blocking
Antifungal Echinocandins ... severe Candida infections ... for Aspergillus infections ... Echinocandins #Antifungal
Amphotericin B - Pharmacology Summary Sheet Class: Polyene Antifungal Mechanism of Action: • Binds to ergosterol → Complexes
Class: Polyene Antifungal ... Lipid Complex), Ambisome ... #Pharmacology #ambisome
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