20 results
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
anticoagulants (DOACs ... #Cancer #Algorithm ... #Anticoagulation ... #Management #Hematology ... #Oncology
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
twitter.com/AmyChung #AntiCoagulation ... #Pharmacology #Pathophysiology ... #Mechanisms #DOAC ... #Hematology
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
DOAC, direct oral ... #DOAC #VTE #Malignancy ... #Anticoagulation ... #Management #Hematology ... #Oncology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
) Cancer-treatment ... thereby leading ... metabolization leading ... #Chemotherapy #Oncology ... #Hematology #Interactions
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... ASA) • Renal Disease ... - Acquired • Anticoagulation ... Coagulation #Bleeding ... Algorithm #Causes #Hematology
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease
Increased Thrombosis 
Increased Platelet-Vesset Wall Interaction 
 •
Thrombosis and Bleeding ... in Liver Disease ... #Thrombosis #Bleeding ... Clot #Cirrhosis #Pathophysiology ... #Hepatology #Liver
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm
Cervical:
 - Anterior
     • Infection
• Kikuchi Disease ... , Breast) • Cancer ... Infection • Cancer ... Algorithm #Causes #Hematology ... #Oncology
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
Sickle Cell Disease ... - Pathophysiology ... of disease and ... #Pathophysiology ... Complications #Hematology
CHA2DS2VASc vs HAS-BLED scores for stroke risk and bleed risk on anticoagulation

C	Congestive Heart Failure	1

H	Hypertension	1

A2	Age >75	2

D	Diabetes Mellitus	1

S2	Stroke,
bleed risk on anticoagulation ... 2 V Vascular disease ... S Stroke 1 B Bleeding ... Stroke #Bleed #Anticoagulation ... AFib #Diagnosis #Hematology
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
screening for disease ... with established disease ... hemophilia treatment center ... those with severe disease ... Management #treatment #hematology