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diagnosis differential algorithm hypocalcemia hematology management workup calcium coagulation prolonged treatment abnormal disorders pathophysiology pt pth adrenal blood clinical evaluation
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Evaluate an Abnormal APTT ... or APTT? ... to identify the cause ... ISNeducation #Abnormal #APTT ... mixing #studies #PTT
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... PTT • Prolonged ... PTT • Prolonged ... PTT • Prolonged ... Diagnosis #Algorithm #Causes
Causes of Hypercalcemia Hypercalcemia due to increased bone Ca2+ resorption: • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... Hypercalcemia ... Immobilization Hypercalcemia ... #Causes #differential ... calcium #high #endocrinology
Causes of Hypercalcemia #Differential #Hypercalcemia #Diagnosis #Causes #Endocrinology
Causes of Hypercalcemia ... #Differential #Hypercalcemia ... #Diagnosis #Causes ... #Endocrinology
Hypercalcemia Workup and Differential Diagnosis Framework 1) Determine whether PTH-dependent 2) Assess for other hormonal causes 3) Assess for
Hypercalcemia Workup ... Determine whether PTH-dependent ... other hormonal causes ... for non-hormonal causes ... Diagnosis #algorithm #endocrinology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
PT and/or aPTT ... typically prolong aPTT ... may prolong the aPTT ... and aPTT 1. ... #aPTT #Prolonged
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Hypercalcemia - ... Algorithm Elevated PTH ... Low PTH: • Elevated ... Diagnosis #Algorithm #causes ... #endocrinology
Causes of Hypercalcemia - Differential Diagnosis Algorithm • Primary Hyperparathyroidism • Possible Familial Hypocalciuric Hypercalcemia
Causes of Hypercalcemia ... Hypocalciuric Hypercalcemia ... • Humoral Hypercalcemia ... Diagnosis #Algorithm #Causes ... #endocrinology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
and aPTT If the ... PT and the aPTT ... Causes include : ... Pre-analytical cause ... #aPTT #Prolonged
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
/PTT • Low plasma ... /INR: ↑ • PTT: ... Treat primary cause ... INR < 2.3 - APTT ... Coagulation #diagnosis #causes
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