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diagnosis differential coagulation disorders workup algorithm blood causes dic disseminated intravascular product reactions treatment activation aggregometry anticoagulant anticoagulation apixaban bleeding
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
/PTT • Low plasma ... /INR: ↑ • PTT: ... INR < 2.3 - APTT ... causes #treatment #management ... #hematology
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
Diagnosis and Management ... /aPTT MAHA likely ... /aPTT normal • ... Differential #Diagnosis #Management ... #Algorithm #hematology
Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
Platelet disorders ... , PT, PTT (diff ... count and platelet ... • Platelet flow ... #disorders #hematology
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
Laboratory • Normal platelet ... 2B) • Normal PT ... INR • Normal aPTT ... Disease #Diagnosis #Hematology
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
< 1800/uL, • platelet ... iron studies, PT ... /aPTT Differential ... Diagnosis #Algorithm #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Thrombocytopenia and Platelet ... History: - Prior platelet ... , aPTT(liver disease ... or if a primary hematologic ... Causes #Workup #hematology
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Coagulation (DIC) Platelet ... thrormbin-induced platelet ... aggregation PT ... , aPTT: • Expected ... Scoring #diagnosis #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
multicomponent complexes on platelets ... Coagulation #Cascade #platelet ... thrombin #clot #PT ... #PTT #diagnosis ... #models #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
/NORMAL PTT: • ... /ABNORMAL PTT: ... Perform a PTT mixing ... /ABNORMAL PTT: ... Differential #Diagnosis #Hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... established disease) • aPTT ... mixing study (aPTT ... Chronic Management ... #treatment #hematology
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