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hematology coagulation differential prolonged treatment disseminated druginduced intravascular lupus rheumatology bleeding bruising comparison dil disorders evaluation hemophilia hemostasis isth ketones
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
APTT Step 1: Is ... the PT or APTT ... Prolonging the PT ... to identify the cause ... #diagnosis #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... /PTT • Low plasma ... Fibrinogen: ↓ • PT ... /INR: ↑ • PTT: ... INR < 2.3 - APTT
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... PT and/or aPTT ... Prothrombin Time (PT ... #PT #aPTT #Prolonged ... #Causes #diagnosis
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
Mixing Study • ... Clotting tests can be abnormal ... PT and/or aPTT) ... #Study #diagnosis ... pathophysiology #hematology #laboratory
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the ... PT and the aPTT ... #PT #aPTT #Prolonged ... #Causes #diagnosis
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... Perform a PTT mixing ... PT/NORMAL PTT: ... ABNORMAL PTT: Prolongation
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
platelet aggregation PT ... , aPTT: • Expected ... using INR use PT ... ISTH #Scoring #diagnosis ... #hematology #laboratory
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
and Management ... established disease) • aPTT ... corrects with a mixing ... study (aPTT may ... cases) • PT/INR
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... activity is the diagnostic ... available for rapid diagnosis ... be performed PT ... , PTT, and fibrinogen
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
calcium-b) • Laboratory ... anti-MPO - Seen with PTU ... • Laboratory ... #rheumatology #diagnosis ... #management
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