13 results
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Diagnosis and Management ... antiglobulin test, PT ... /aPTT MAHA likely ... hemosiderin • PT ... /aPTT normal •
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... /PTT • Low plasma ... Fibrinogen: ↓ • PT ... /INR: ↑ • PTT: ... INR < 2.3 - APTT
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
2B) • Normal PT ... INR • Normal aPTT ... factor VIII) Treatment
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... established disease) • aPTT ... mixing study (aPTT ... mild cases) • PT ... Chronic Management
REBEL Review 71: Treatment of Thyroid Storm 

Propranolol 
Esmolol 
Propylthiouracil (PTU) 
Methimazole 
Saturated Solution of Potassium
REBEL Review 71: Treatment ... Propylthiouracil (PTU ... Hydrocortisone #endocrinology ... hyperthyroidism #table #management ... #treatment #pharmacology
Postpartum Hemorrhage - Differential Diagnosis and Management 
Uterine Atony (80%) - Most PPH Will respond to
Diagnosis and Management ... CBC, fibrinogen, PT ... /PTT • Treat with ... unresponsive to usual treatment ... Differential #Diagnosis #Management
REBEL Review 79: Treatment of Hemophilia 

Walkina Out of Pt Room, You Should Know... 
1. Type
REBEL Review 79: Treatment ... Walkina Out of Pt ... hemophilia #hematology #management ... #treatment #dosing
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Hypofibrinogenemia • ↑ PT ... ↑ PTT • ↑ Fibrin ... Treatment: • Corticosteroids ... Syndrome #Diagnosis #Management
Diabetic Myonecrosis (Diabetic Muscle Infarction)
 • Spontaneous ischemic necrosis of skeletal muscle (anterior thigh or calf)
Suspect in diabetic pt ... weeks with above treatment ... Infarction #diagnosis #management
Ketosis Disorders
Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
IVF or PO): The pt ... differential #diagnosis #management ... #endocrinology