11 results
diagnosis differential rheumatology sle causes erythematosus hcq hemolysis hydroxychloroquine medications systemic acid adverseeffects algorithm anemia benefits bleeding bruising classification colchicine
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Criteria for Systemic Lupus ... Acute cutaneous lupus ... pericarditis • Hematologic ... Thrombocytopenia, Autoimmune hemolysis ... Erythematosus #diagnosis #rheumatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Diseases: • Systemic lupus ... Antibody-mediated hemolysis ... Differential #Diagnosis #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... Extravascular Hemolysis ... usually IgG) (e.g. lupus ... differential #diagnosis #hematology
Tranexamic Acid - Indications and Pharmacology Pharmacokinetics: • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
Indications and Pharmacology ... Post-partum, ICH/TBI, Hemoptysis ... #Indications #Pharmacology ... #hematology
Hydroxychloroquine - Risks and Benefits in Lupus Benefits: ↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
and Benefits in Lupus ... limited) risk of hemolysis ... Risks #Benefits #Lupus ... #pharmacology # ... #sideeffects #rheumatology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement #SLE #rheumatology ... #pharmacology # ... levels #lupus #management
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
primary or secondary hemostasis ... Autoimmune Vasculitis (lupus ... Algorithm #Causes #dermatology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Disorders of Hemostasis ... inhibitor and lupus ... Willebrand syndrome • Lupus ... Bleeding #Bruising #Hemostasis ... Differential #Diagnosis #Hematology
Medications to Avoid in Patients with G6PD Deficiency Due to Risk of Hemolysis - Chloroquine (Aralen)*
Due to Risk of Hemolysis ... G6PD #Deficiency #Hemolysis ... Differential #Diagnosis #Pharmacology ... #Hematology
Drug Induced Systemic Lupus Erythematosus > 100 drugs have been associated with drug-induced SLE High risk (>5%): •
Induced Systemic Lupus ... SLE #Systemic #Lupus ... medications #drugs #pharmacology ... differential #diagnosis #rheumatology
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