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diagnosis hematology differential algorithm hemolytic management extravascular intravascular macrocytic morphology aafp ascorbicacid bloodcell cellulitis classification clinical decrease dermatology disorders dm2
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... #Hemolytic #Anemia ... #Differential #Causes ... #Workup #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Burr Cell RBC (Echinocyte ... Microangiopathic Hemolytic ... Bite Cell RBC: G6PD ... Cold autoimmune hemolytic ... hematology #microscopy #atlas
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): ... ) (e.g. lupus, CLL ... • Intrinsic RBC ... Extravascular #Causes
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology ... Atlas • Microcytic ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... #Morphology #Atlas
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... DAT (-) → Sickle Cell ... & microcytic RBCs ... anemia (TTP, HUS ... Diagnosis #Algorithm #causes
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... • Sickle cell ... elliptocytosis - RBC ... anemia • ... Diagnosis #Algorithm #Causes
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... Hypertriglyceridemia • Uremia ... blood loss • Hemolytic ... anemia • Splenomegaly ... , Sickle Cell
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Mean corpuscular (cell ... Red cell distribution ... acute blood loss, hemolysis ... Algorithm #Diagnosis #Workup
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
(RBC = red blood ... Hemorrhage or hemolysis ... the most likely cause ... recovery also causes ... of the initial work-up
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... hypertension • Unusual RBC ... #Anemia #Differential ... Diagnosis #Algorithm #workup
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