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diagnosis hematology algorithm hemolytic causes intravascular management morphology agglutinin antibody bloodcell classification cold disease hodgkins key lymphoma mcv microcytic microscopy
Evaluation of Patients with Anemia Microcytic, Normocytic, Macrocytic, Hemolytic (Intravascular and Extravascular) #Diagnosis #Anemia #Workup #Macrocytic #Microcytic #Normocytic
Patients with Anemia ... , Macrocytic, Hemolytic ... and Extravascular ... #Workup #Macrocytic ... #Differential #
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... idiopathic) - Autoimmune ... • Intrinsic RBC ... #Hemolytic #Intravascular ... #Causes #differential
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Hemolysis - Differential ... Cold AIHA • Alloimmune ... elliptocytosis - RBC ... anemia • ... Differential #Diagnosis
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... ) Morphology Atlas ... Lead poisoning • Macrocytic ... spherocytosis, Hemolytic ... key #diagnosis #differential
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
(sometimes) Macrocytic ... hemolytic anemia ... hemolytic anemia ... #Morphology #differential ... hematology #microscopy #atlas
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Hemolytic Anemia ... : macrocytic > normocytic ... ↑ LDH • Anti-RBC ... • Blood smear: Differential ... #Hemolytic #Anemia
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... , CKD • Hemolytic ... Spherocytosis, G6PD, PK, HbC ... - Extrinsic: Autoimmune ... Infections Macrocytic
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... - Differential ... RBCs, DAT (-) → ... idiopathic, malignancy, autoimmune ... #Anemia #Differential
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... elliptocytosis, autoimmune ... #Anemia #Differential ... Diagnosis #Algorithm #workup
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... anemia • Cold ... CLL (older) • Autoimmune ... younger pts) Differential ... causing intravascular
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