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Iron Deficiency Anemia vs Anemia of Chronic Disease - Laboratory Testing

SUMMARY:
 - RDW, FEP, serum iron,
Iron Deficiency ... Anemia vs Anemia ... of Chronic Disease ... - Laboratory Testing ... #Deficiency #Anemia
Anemia - Underproduction Diagnostic Algorithm
 - Iron deficiency anemia
 - Anemia of chronic inflammation
 - Anemia
Anemia - Underproduction ... - Iron deficiency ... anemia - Anemia ... chronic kidney disease ... - Vitamin B12
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (<80 fL) • Iron ... Poisoning • Anemia ... Marrow Failure • Anemia ... (>100 fL) • B12
Gastrointestinal Evaluation of Iron Deficiency Anemia
In patients with anemia, diagnose iron deficiency if:
 • Ferritin <
Deficiency Anemia ... patients with anemia ... • Additional laboratory ... Test for celiac disease ... #Deficiency #Anemia
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
to Anemia - Differential ... Sideroblastic anemia ... ACD, Aplastic anemia ... , B12 deficiency ... MatthewHoMD #Anemia
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
deficiency anemia ... anemia (sometimes ... Sideroblastic anemia ... Macrocytic RBC: Vitamin B12 ... deficiency anemia
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... B12/Folate Deficiency ... • Aplastic Anemia ... • Anemia of Chronic ... Non-lmmune #Anemia
For an elderly patient with multiple comorbidities it can be challenging to determine if their anemia
determine if their anemia ... as anemia of chronic ... disease. ... #Deficiency #Anemia ... #Algorithm #Ferritin
Causes of False Elevation and Reduction in HbA1c

== False Elevation ==
Decreased RBC turnover 
• Iron, B-12,
RBC turnover • Iron ... , B-12, or folate ... deficiency • ... • Hemolytic anemia ... End-stage renal disease
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
Framework for Anemia ... Microcytic" • Iron ... thalassemia • Anemia ... Normocytic" • Anemia ... Megaloblastic: Vitamin B12