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diagnosis hematology algorithm causes macrocytosis mcv aafp atlas bloodcell calculation decrease dm2 elevatedmcv elevation false folicacid hba1c hgba1c homocysteine increase
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Volume (MCV) - Differential ... Neutrophils - Low RBC ... Folate • ... Dietary Deficiency ... and Folate Deficiency
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
) Morphology Microcytic ... (sometimes) Macrocytic ... RBC: Vitamin B12 ... or Folate deficiency ... #Morphology #differential
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... Spherocytosis, G6PD, PK, HbC ... Infections Macrocytic ... Megaloblastic: Folate ... deficiency, B12
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
evaluation of macrocytic ... (RBC = red blood ... B12 deficiency ... deficiency. ... #Folate #FolicAcid
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
MCV - >96fL - "Macrocytic ... Megaloblastic: Vitamin ... B12 deficiency, ... Folate deficiency ... morphologic #mcv #differential
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
turnover • Iron, B-12 ... , or folate deficiency ... • Hemolytic anemia ... glycosylation • Vitamin ... Diagnosis #DM2 #Differential
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
Vitamin B12 (Cobalamin ... ) Deficiency Etiology ... : • Worsening macrocytic ... • Labs: - CBC ... #B12 #Cobalamin
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... chronic blood loss), Vitamin ... B12, Folate • ... , Intrinsic RBC ... #differential #
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
common cytopenia: Macrocytic ... • Nutritional: vitamin ... B12 or folic acid ... deficiency • Exposure ... blood count with differential
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