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diagnosis differential management pathophysiology syndrome hematology treatment algorithm nutrition rheumatology endocrinology geriatrics infectiousdiseases nephrology oncology physicalexam workup abnormal celiac classification
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Clinically Important ... Vitamins and Vitamin Deficiency ... Wernicke-Korsakoff syndrome ... differential #diagnosis #signs ... #symptoms #nutrition
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... • Dietary Deficiency ... Myelodysplastic Syndromes ... and Folate Deficiency ... • Liver Disease
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
chronic kidney disease ... Megaloblastic: Vitamin B12 ... Alcohol use, Liver disease ... Myelodysplastic syndrome ... differential #diagnosis #causes
Suspected Celiac Disease - Diagnosis Algorithm Celiac disease suspected: • Signs and symptoms of celiac disease •
suspected: • Signs ... and symptoms of ... • Iron-deficiency ... anemia unresponsive ... without discernable cause
Causes of Low Vitamin B12 Levels Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people Autoimmune
Causes of Low Vitamin ... B12 Levels Low ... vitamin B12 intake ... and Sjögren's syndrome ... , coeliac disease
Risk Factors and Signs of Copper Deficiency Risk Factors: • Gastrointestinal: Previous upper bowel resection/bariatric surgery, Inflammatory
of Copper Deficiency ... diarrhoea, Short bowel syndrome ... Haematological: Anaemia ... drkeithsiau #Copper #Deficiency ... #riskfactors #symptoms
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... and petechiae Causes ... , GATA2 deficiency ... , CTLA4 deficiency ... • Improve the symptoms
Korsakoff Syndrome Clinical Findings: • Confabulation: Usually initial phase of the disease • Anterograde amnesia: Memory impairment
Clinical Findings ... initial phase of the disease ... • Anterograde amnesia ... presentation of Thiamine deficiency ... #neurology #diagnosis
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
fatigue despite clinical ... restricted diet/deficiency ... symptoms even if ... fatigue despite disease ... /other causes •
Etiologies of Peripheral Neuropathy • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism • Medication-induced: ART, Antibiotics,
Nutritional: DiabetesB12 deficiency ... , Uremia/ESRD, Hypothyroidism ... Paraprotein-associated (POEMS syndrome ... differential #diagnosis #causes ... #neurology
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