37 results
Anemia - Underproduction Diagnostic Algorithm
 - Iron deficiency anemia
 - Anemia of chronic inflammation
 - Anemia
Diagnostic Algorithm ... - Iron deficiency ... disease - Vitamin B12 ... and/or folate deficiency ... #workup
Approach to Hypoproliferative Macrocytic Anemia

 • 812, Folate Deficiency
 • MDS+
 • Hypothyroid
 • Liver Disease
812, Folate ... Deficiency • ... #differential #diagnosis ... #algorithm #hematology ... #workup
Clinically Important Vitamins and Vitamin Deficiency States
Fat-soluble Vitamins: 
 • Vitamin A - Xerophthalmia, night blindness,
Clinically Important ... Vitamins and Vitamin Deficiency ... Wernicke-Korsakoff syndrome ... #differential #diagnosis ... #signs #symptoms
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
- Differential Diagnosis ... • Dietary Deficiency ... Myelodysplastic Syndromes ... and Folate Deficiency ... #Differential #Diagnosis
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
Diagnostic Framework ... Megaloblastic: Vitamin B12 ... Myelodysplastic syndrome ... #differential #diagnosis ... #causes #hematology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
- Differential Diagnosis ... • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... consumption • Vitamin B12 ... #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
- Differential Diagnosis ... Megakaryopoiesis • Aplastic Anemia ... Megakaryopoiesis • B12 ... Deficiency • ... Non-lmmune: • HELLP Syndrome
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
Differential diagnosis ... crisis • Severe B12 ... deficiency • Mechanical ... macroangiopathic hemolytic anemia ... #hematology #hemolysis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
for workup, including ... Acute hemolysis, deficiency ... anemia, Rebound ... Inflammatory Conditions: Rheumatologic ... Kawasaki, Nephrotic syndrome
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Clinical Presentation ... , GATA2 deficiency ... , CTLA4 deficiency ... • Improve the symptoms ... #diagnosis #management