18 results
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Disease Clinical ... arthritis, Skin rash ... Diaqnoses: • Infectious ... #management #treatment ... #rheumatology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Differential Diagnosis Algorithm ... Renal Disease, Liver ... Inflammation, Chronic Infection ... (>100 fL) • B12 ... #Causes #Hematology
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... Disease (AOSD) ... maculopapular rash ... #Disease #AOSD ... #rheumatology #diagnosis
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Macroangiopathic, Infections ... Folate deficiency, B12 ... Non-megaloblastic: Liver ... disease, Alcoholism ... Differential #Diagnosis #hematology
Adult Onset Still's Disease - Yamaguchi Criteria
Major criteria:
 - Fever >= 39C lasting >= 1 weeks
Adult Onset Still's ... - Typical skin rash ... Abnormalities in liver ... #AdultOnset #Stills ... #Major #Minor #Rheumatology
Vibrio Vulnificus skin infection
Cirrhosis w/recent consumption of raw oysters w/rapidly evolving rash. 
Vibrio vulnificus part of
onset of fever, chills ... sepsis: chronic liver ... Diseases Fellowship ... #dermatology #legs ... #clinical #photo
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... /splenomegaly, liver ... Treatment - Mild ... : NSAIDS Treatment ... #diagnosis #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
• Adult-onset Still ... Petechial or purpuric rash ... SLE], AOSD) • Infection ... Diagnosis #Management #Hematology ... #Rheumatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
69% - Malar rash ... - Neurological 12% ... Other auto-immune, Infectious ... Multiple sclerosis, Still's ... #differential #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... +, Adult-onset Still ... disease, Infection ... #summary #rheumatology