63 results
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Wiskott-Aldrich syndrome ... erythematosus • HLH ... consumption • Vitamin B12 ... deficiency Infections ... Differential #Diagnosis #Hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... • Autoimmune diseases ... Treatment: • ... #summary #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Megakaryopoiesis • B12 ... Alloimmune • anti-HLA ... Non-lmmune: • HELLP Syndrome ... Vasculitis • Infection ... #Hematology
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
infection Malar ... infection • Lyme ... disease • Rosacea ... Antiphospholipid-antibody syndrome ... differential #diagnosis #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... syndrome associated ... age, however the disease ... : • Infection ... #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lymphohistiocytosis (HLH ... SLE], AOSD) • Infection ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... SLE) - Viral infections ... Kasabach-Merritt syndrome ... Differential #Diagnosis #hematology ... #rheumatology #
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group

< 5%
vasculitis - Diagnosis, causes ... manifestations - Skin ... neuropathy Treatment ... with refractory disease ... Cryoglobulinemia #Vasculitis #Rheumatology
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Framework Non-Infectious ... arteritis, Cogan's Syndrome ... , Sarcoidosis, HLA-B27 ... rare), Idiopathic Infectious ... Differential #Diagnosis #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Treatment
Primary HLH:
 - HLH-94 Protocol
    • Dexamethasone
) Treatment Primary ... associated with infection ... or autoimmune disease ... for refractory disease ... #hematology