31 results
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Human parvovirus B19 ... Malar rash • SLE ... infection • Lyme disease ... IBD • RA • SLE ... Antiphospholipid-antibody syndrome
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Associated with skin ... block • Sjogren syndrome ... polymyositis overlap syndrome ... Treatment: • ... Summary #diagnosis #rheumatology
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
most frequent skin ... appearing during the disease ... dermatomyositis, SLE ... #oncology #clinical ... #skin
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... Clinical Presentation ... Fever is the main clinical ... erythematosus [SLE ... Treatment: • Corticosteroids
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
(Clinical Dx). ... oral ulcers in 12 ... Oral aphthae : SLE ... • Arthritis: SLE ... Arthritis, AS Treatment
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... : • Common Clinical ... nose chondritis, skin ... thromboembolic disease ... polyarteritis nodosa (12%
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... 3rd Decade Skin ... Malignancy (e.g. hematologic ... Clinical Features ... Chronic B-cell activation
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... Systemic Lupus (SLE ... Sjögrens (15%) Skin ... Demyelinating syndromes ... pain (20%) Renal disease
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 ... accumulation of clinical ... Assessment • Clinical ... : SLE+++, Adult-onset ... Still disease,
Behcet's Syndrome - Diagnosis
Diagnostic Criteria for Behget's Syndrome (International Study Group for Behget's Disease):
 • Recurrent,
episodes within a 12 ... vasculitis - Skin ... test Most Common Clinical ... Wide variety of skin ... #criteria #rheumatology