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diagnosis management differential syndrome lupus algorithm dermatology systemic classification vasculitis anemia erythematosus pharmacology summary arthritis hepatology joint leukemia pain antibody
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
• Immunologic Workup ... Positive in 60-80% of cases ... life-threatening • Treatment ... Evolution: Chronic disease ... Management #Summary #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Workup History ... PT, aPTT(liver disease ... function test, ANA ... (e.g., SLE), anti-phospholipid ... #Workup #hematology
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
chronic kidney disease ... - Vitamin B12 ... and/or folate deficiency ... Underproduction #Algorithm #hematology ... #differential #workup
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease ... Diagnosis #Algorithm #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... • Immunologic Workup ... life-threatening • Treatment ... Evolution: Chronic disease ... comparison #table #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Splenomegaly - CTD (SLE ... Cryoglobulinemia (MIXED) • ANCA ... Associated - SLE ... Differential #Diagnosis #hematology ... #rheumatology #
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Antinuclear (ANA ... • Specific for SLE ... Treatment: • ... Ann Marie Kumfer ... Summary #diagnosis #rheumatology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... • Pancreatic Disease ... and Folate Deficiency ... • Liver Disease ... #Hematology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Nodosa (PAN), ANCA ... ) • Rheumatic Diseases ... : IgG4-Related Disease ... erythematosus (SLE ... Differential #Diagnosis #rheumatology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
ULN R - Renal disease ... Causes of false- ... Other causes of ... MGUS #diagnosis #hematology ... #oncology
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