41 results
Causes of Vitamin B12 Deficiency - Cobalamin
Decreased Intake
Pancreas: Insufficiency
Intestine: SIBO, Celiac disease, IBD, Lymphoma, Amyloidosis, Resection,
Causes of Vitamin ... B12 Deficiency ... Stomach: Pernicious anemia ... Gastritis Other: Medications ... #differential #diagnosis
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... - Differential Diagnosis ... • Dietary Deficiency ... Myelodysplastic Syndromes ... #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic Anemia ... Megakaryopoiesis • B12 ... Non-lmmune: • HELLP Syndrome ... #Hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
Diagnostic Framework ... Megaloblastic: Vitamin B12 ... Myelodysplastic syndrome ... #differential #diagnosis ... #causes #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... - Differential Diagnosis ... (>100 fL) • B12 ... #Algorithm #Causes ... #Hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Causes of Neutropenia ... Toxins • Aplastic Anemia ... Myelodysplasia Nutritional deficiency ... : • B12/folate ... #Hematology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
- Differential Diagnosis ... • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... consumption • Vitamin B12 ... #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... • B12/Folate ... Deficiency • Aplastic ... #Algorithm #Causes ... #Hematology
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
Differential diagnosis ... crisis • Severe B12 ... deficiency • Mechanical ... macroangiopathic hemolytic anemia ... #hematology #hemolysis
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
and petechiae Causes ... , GATA2 deficiency ... - Antithyroid medications ... Treatment: ... #diagnosis #management