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diagnosis differential management myelodysplastic algorithm aplastic classification elevation emergencies fat fatrbc hemeonc hepatology lactate lactic macrocytic mnemonic myelodysplasia oncologic rbc
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... Megakaryopoiesis • B12 ... Non-lmmune: • HELLP Syndrome ... #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute leukemia ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... , GATA2 deficiency ... virus (EBV) • Leukemia ... Treatment: ... #oncology #hematology
FAT RBC Mnemonic for Causes of Macrocytic Anemia (MCV > 100) F - Folate (Fetus) and B12 Deficiency
Folate (Fetus) and B12 ... Deficiency - Impairs ... Marrow Disorders (MDS ... , leukemia) C - ... Cirrhosis, Chemicals
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Hairy Cell Leukemia ... Nutritional: vitamin B12 ... • Copper deficiency ... #diagnosis #hematology ... #oncology
Causes of Anemia in Cirrhosis - Differential Diagnosis Framework LOW RETIC INDEX - ↓ PRODUCTION • Vitamin
Causes of Anemia ... in Cirrhosis - ... PRODUCTION • Vitamin B12 ... Destruction: Zieve's syndrome ... #Diagnosis #Hepatology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
perfusion - shock->treatments ... before beginning treatment ... - Compartment syndrome ... 30mmHg) - Severe anemia ... effect - Thiamine deficiency
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... ): - Hematologic ... Treat underlying cause ... Usually myeloid leukemias ... treat - Calcium > 12
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... primary biliary cirrhosis ... renal tubular acidosis ... Nephrogenic DI Hematologic ... Adenocarcinoma Treatment
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