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diagnosis management algorithm differential causes chronic hemeonc lymphocytic myelodysplastic acidosis aplastic cancer elevation emergencies erythematosus hodgkins lactate lactic lupus lymphoma
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... Megakaryopoiesis • B12 ... ITP • SLE • CLL ... Non-lmmune: • HELLP Syndrome
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... microglobulin Treatment ... • Richter’s Syndrome ... #diagnosis #workup ... #oncology #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... cytopenias (usually anemia ... transformation to acute leukemia ... Allogeneic stem cell ... #hematology #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Cell Leukemia ... Nutritional: vitamin B12 ... #diagnosis #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
, GATA2 deficiency ... , CTLA4 deficiency ... virus (EBV) • Leukemia ... Treatment: ... #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
(CLL) - Summary ... 5) Symptoms of anemia ... Lauren Banaszak, MD ... uw_IMresidency #CLL ... #oncology #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
for workup, including ... Acute hemolysis, deficiency ... anemia, Rebound ... effect from treatment ... Kawasaki, Nephrotic syndrome
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
full infectious work-up ... days → add fungal work-up ... ): - Hematologic ... Usually myeloid leukemias ... ± tocilizumab; call
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... Immune hemolytic anemia ... Hodgkin Lymphoma Workup ... Hodgkin Lymphoma Treatment ... #hematology #oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... disease • Prolidase deficiency ... lymphopenia, low PLT • Anemia ... (C3 and C4) • ds-DNA ... Hodgkin lymphoma and leukemia
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