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diagnosis differential management algorithm vitamin bariatric bypass chronic cll deficiencies gastric leukemia lymphocytic myelodysplastic neurology nutrient signs aplastic atrophicglossitis b1
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... : vitamin B12 or ... • Copper deficiency ... #diagnosis #hematology ... #oncology
Risk Factors and Signs of Copper Deficiency Risk Factors: • Gastrointestinal: Previous upper bowel resection/bariatric surgery, Inflammatory
Deficiency Risk ... diarrhoea, Short bowel syndrome ... dental fixatives, Treatment ... Haematological: Anaemia ... #riskfactors #symptoms
Wernicke Encephalopathy - Acute B1 (Thiamine) Deficiency - Diagnosis and Management Diagnosis - Caine Criteria (2 of
not present in upper ... Anorexia nervosa Treatment ... can improve symptoms ... development of Korsakoff syndrome ... (chronic B1 deficiency
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Vitamins and Vitamin Deficiency ... Wernicke-Korsakoff syndrome ... gestation • Vitamin B12 ... diagnosis #signs #symptoms ... #nutrition
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
• Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Antibody-mediated hemolysis Nutritional ... consumption • Vitamin B12 ... Differential #Diagnosis #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
, GATA2 deficiency ... , CTLA4 deficiency ... Treatment: ... • Improve the symptoms ... #oncology #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... cytopenias (usually anemia ... #MDS #Diagnosis ... #Management #treatment ... #hematology #oncology
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Anemia - Differential ... Gastrectomy, WHDA syndrome ... , Copper deficiency ... Matthew Ho, MD ... Algorithm #ferritin #hematology
Nutrient Deficiencies and Supplementation Post Gastric Bypass Surgery Nutrient Deficiencies: • Most frequent in the malabsorptive surgeries
folate, iron, B12 ... Pervasive neurologic symptoms ... Phos, Ca+, Bl, B12 ... protein, Vit E, Copper ... gastroenterology #nutrition
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Malaria, babesia - Nutritional ... : B12, copper, folate ... infection (TB), MDS ... antiphospholipid syndrome ... Diagnosis #Framework #hematology
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