35 results
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... • Small Bowel Disorder ... Myelodysplastic Syndromes ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Causes of Thrombocytosis ... • Rheumatic disorders ... effect following treatment ... Iron deficiency anemia ... #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Deficiency • B12 ... • RBC Membrane Disorder ... RBC Metabolism Disorder ... Diagnosis #Algorithm #Causes ... #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic anemia ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... Differential #Diagnosis #hematology ... #nonpalpable #dermatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic Anemia ... Megakaryopoiesis • B12 ... Non-lmmune: • HELLP Syndrome ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
and Platelet Disorders ... (CVID, WAS), (neurologic ... changes), high MCV anemia ... or if a primary hematologic ... #Workup #hematology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... Chronic inflammatory disorders ... Myelodysplastic syndrome ... #hematology #secondary
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
Framework for Anemia ... Megaloblastic: Vitamin B12 ... Myelodysplastic syndrome ... differential #diagnosis #causes ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... cytopenias (usually anemia ... only curative treatment ... #hematology #oncology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... lymphoproliferative disorders ... differential #diagnosis #hematology ... #anemia