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diagnosis differential management algorithm causes symptoms dermatology hemeonc hemolysis leukemia workup aplastic atlas chronic classification disease erythematosus hemophagocytic hlh lupus
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
syndrome (ST-HUS ... organ or stem cell ... crisis • Severe B12 ... anemia" • HELLP ... differential #diagnosis #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach to Anemia ... -100): • Non-hemolytic ... , CKD • Hemolytic ... Folate deficiency, B12 ... Differential #Diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... uremic syndrome ... ) (e.g. lupus, CLL ... differential #diagnosis #hematology ... #anemia
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Corpuscular Volume (MCV ... • Bleeding • Hemolysis ... (>100 fL) • B12 ... #MCV #Classification ... Algorithm #Causes #Hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
) Low MCV - <80fL ... patients) Normal MCV ... Megaloblastic: Vitamin B12 ... Myelodysplastic syndrome ... diagnosis #causes #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Macrocytic RBC: Vitamin B12 ... Microangiopathic Hemolytic ... spherocytosis, Autoimmune hemolytic ... Cold autoimmune hemolytic ... differential #diagnosis #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Myelodysplastic syndrome ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... uremic syndrome ... #differential #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Corpuscular Volume (MCV ... - Low Serum B12 ... - Low Serum B12 ... Myelodysplastic Syndromes ... Algorithm #Causes #Hematology
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... anemia (MCV 80- ... Pancytopenia is a hematologic ... a decrease in all ... hemoglobin of less than 12
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Antibody-mediated hemolysis ... consumption • Vitamin B12 ... Differential #Diagnosis #Hematology
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