5969 results
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm

1. Definition: T.bili elevation + >20% conjugated
2. Obtain RUQ
- Differential Diagnosis ... Hyperbilirubinemia #direct #bilirubin ... #Differential #Diagnosis ... gastroenterology #hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Phosphatase and Bilirubin ... initial insult Bilirubin ... ASTALT #AlkPhos #Bilirubin ... #Hepatology #Pathophysiology ... #Diagnosis #LFTs
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
birth with serum bilirubin ... associated with bilirubin ... in conjugated bilirubin ... in conjugated bilirubin ... #hepatology #diagnosis
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
in bone Total bilirubin ... TBili) Direct bilirubin ... Indirect bilirubin ... Interpretation #diagnosis ... #hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
fold elevation, Bilirubin ... fold elevation, Bilirubin ... but variable ++, Bilirubin ... Disease #Pregnancy #hepatology ... #differential #diagnosis
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
and unconjugated bilirubin ... and excretion of bilirubin ... LiverFailure #Hepatic #Hepatology ... #Laboratory #Diagnosis
Ascites - Diagnostic Approach and Differential Diagnosis
The most common causes: cirrhosis, malignancy and heart failure. Approx
Ascites - Diagnostic ... and Differential Diagnosis ... brown: elevated bilirubin ... chylous ascites), bilirubin ... #hepatology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis ... - Serum total bilirubin ... Autoimmune #Hepatitis #Diagnosis ... #Hepatology #AIH
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
hepatocellular injury • Bilirubin ... week • Direct bilirubin ... Elevation: • Bilirubin ... liver #chemistry #diagnosis ... #differential #Hepatology
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
Clinical diagnosis ... • Serum total bilirubin ... #diagnosis #Alcoholic ... Hepatitis #AH #hepatology