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diagnosis management differential algorithm aplastic causes chronic cll hodgkins lymphocytic lymphoma mds myelodysplastic syndrome workup apml atlas cancer cell classification
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
fever, joint pain, bleeding ... night sweats, bleeding ... Petechiae, bruising, bleeding ... - infiltrates (anemia ... #Hematology #Oncology
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Features of hematologic ... B-symptoms, bruising/bleeding ... hepatomegaly • Labs: anemia ... predominant immature cells ... #WBC #Leukemoid
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
- History of Bleeding ... Lymphoblastic Leukemia ... Reed-Sternberg Cells ... Algorithm #Causes #Hematology ... #Oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
neutropenia • Mucosal bleeding ... Treatment: • Consider ... to MDS or acute leukemia ... diagnosis #management #treatment ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... cytopenias (usually anemia ... transformation to acute leukemia ... only curative treatment ... #hematology #oncology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
• Sickle cells ... alcoholism • Burr cells ... Liver diseases, Bleeding ... PD deficiency, Pulmonary ... #differential #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
• Most common leukemia ... lymphocytes, smudge cells ... 5) Symptoms of anemia ... marrow failure with anemia ... #oncology #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... ecchymoses, mucosal bleeding ... virus (EBV) • Leukemia ... Treatment: ... #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
or basket cells ... • Neutropenia, anemia ... microglobulin Treatment ... diagnosis #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
unusual bruising or bleeding ... are caused by bleeding ... • Hairy Cell Leukemia ... Syndromes #diagnosis #hematology ... #oncology
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