39 results
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
Von Willebrand Disease ... common inherited bleeding ... factor VIII) Treatment ... VonWillebrand #Disease ... #Diagnosis #Hematology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
anemia, Liver diseases ... , Liver diseases ... , Bleeding gastric ... PD deficiency, Pulmonary ... #differential #hematology
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
screening for disease ... with established disease ... Classify severity Treatment ... by a hemophilia treatment ... #hematology
Managing warfarin INR

Warfarin dosage must be individualized according to the patient's response to the drug, and
lead to severe bleeding ... #pharmacology #treatment ... #decisionaid #cardiology ... #hematology #warfarin
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
Sickle Cell Disease ... Pathophysiology of disease ... membrane damage leading ... the sickle red cells ... Complications #Hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
type (B cell, T cells ... natural killer (NK) cells ... Hepatosplenomegaly, cytopenias(bleeding ... Lymphomas • Other hematologic ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Schistocytes, helmet cells ... • Severe Liver Disease ... Treatment: ... diagnosis #causes #treatment ... #management #hematology
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
thrombocythemia), Autoimmune disease ... adsorption onto cancer cells ... Diagnosis #Management #treatment ... #hematology #differential
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... night sweats, bleeding ... manifestations, hypoxia, CXR ... • Significant bleeding ... #Leukemia #Hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... Release from blast cells ... common • Imaging: CXR ... - pulmonary opacities ... diagnosis #management #hematology