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diagnosis rheumatology dermatology algorithm erythematosus sle classification symptoms systemic acute aki arteritis autoimmune bruising clues cryofibrinogenemia cryoglobulinemia cutaneous dermatologic dermpath
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
immune system, leading ... • They can cause ... Cause Organ Damage ... Syndrome: • Clinical ... (e.g. systemic lupus
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Rash - Differential ... (lupus, RA, Sjogren's ... immunoglobulins & cryoglobulins ... #Differential #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... mucositis - Rash ... such as systemic lupus ... purpura: strong sign ... Serologies for Cryoglobulins
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... of Systemic Lupus ... Photosensitivity, Butterfly rash ... , Vasculitis, Purpura ... erythematosus #signs
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... #dermpath #dermatology ... #semiology #signs ... lesions #diagnosis #clinical ... pathology #lesions #differential
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
everywhere) 2) A rash ... the face (many differential ... 3) Limb oedema leading ... 6) An annular rash ... erythematosus #rheumatology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
osmolarity If cause ... investigations depending on clinical ... context and signs ... Glomerulonephritis / Vasculits ... immunoglobulins, cryoglobulins
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Paradoxical spontaneous bleeding ... malignancies, vasculitis ... Diagnosis: • + Clinical ... • Negative causes ... #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... permanent alopecia Differential ... ANCA-associated vasculitis ... Malignancy (e.g. hematologic ... lymphoproliferative syndrome Clinical
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... Maculopapular rash ... reticularis Differential ... #rash #diagnosis
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