11 results
diagnosis differential algorithm hepatology management anemia bruising classification hyperbilirubinemia types antibody aplastic autoimmune blood congenital conjugated cryoglobulinemia cryoglobulins disease hemolytic
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
haptoglobin ↑ indirect ... bilirubin, ↑ LDH ... autoantibodies: positive direct ... 2) LOOK FOR a cause ... management #treatment #rheumatology
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm 1. Definition: T.bili elevation + >20% conjugated 2. Obtain RUQ
non-ICU vs ICU causes ... Hyperbilirubinemia #direct ... #bilirubin #Differential ... Diagnosis #Algorithm #gastroenterology ... #hepatology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... - Quantitative Defect ... Coagulation #Bleeding ... Diagnosis #Algorithm #Causes ... #Hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
decrease in most cases ... platelet number Direct ... bilirubin - Mild-to-moderate ... hematuria (without casts ... Diagnosis #Workup #Hematology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
and stress may cause ... the blood • Defect ... • Defect in secretion ... #hepatology #diagnosis ... #gastroenterology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
or Qualitative defect ... dabigatran, argatroban, direct ... discern these causes ... Anticoagulants (warfarin, direct ... Differential #Diagnosis #Hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... Half-life: 1 week • Direct ... bilirubin: ↑ ... RBC (hemolysis, bleeding ... diagnosis #algorithm #hepatology
Von Willebrand Disease Classification Type 1 (Accounts for ~3/4 of cases): • Defect: Quantitative defect (i.e. not
Accounts for ~3/4 of cases ... Autosomal dominant • Bleeding ... (uncommon) • Bleeding ... recessive • Bleeding ... Types #diagnosis #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Mechanisms: • Direct ... ecchymoses, mucosal bleeding ... and petechiae Causes ... Anemia #oncology #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
immune system, leading ... • They can cause ... Cryoglobulins Cause ... • Cryocrit - Detect ... classification #rheumatology
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