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diagnosis rheumatology management differential druginduced erythematosus hcq pharmacology treatment workup adverseeffects approach arthritis benefits cerebritis classification clues cns comparison cryoglobulinemia
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Hydroxychloroquine ... Measurement in SLE ... #Measurement #SLE ... #rheumatology # ... pharmacology #levels #lupus
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... Discontinuation of causal ... drug +++, Hydroxychloroquine ... Erythematosus (SLE ... #table #rheumatology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Differential Diagnosis Algorithm ... • Systemic Lupus ... Leukemia - History of Bleeding ... #Causes #Hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... autoantibodies that will cause ... inflammation, leading ... Erythematosus #SLE ... CNS #neurology #rheumatology
Hydroxychloroquine - Risks and Benefits in Lupus Benefits: ↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
Hydroxychloroquine ... and Benefits in Lupus ... other medications leading ... Risks #Benefits #Lupus ... #sideeffects #rheumatology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
to think about lupus ... 3) Limb oedema leading ... children (pediatric SLE ... #diagnosis #sle ... erythematosus #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
immune system, leading ... • They can cause ... Cryoglobulins Cause ... (e.g. systemic lupus ... erythematosus (SLE
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... an underlying cause ... : neuro, heme (bleeding ... Better call hematology ... some time, let’s see
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
spondyloarthropathies, lupus ... Like in this case ... get bacterial seeding ... Chronic = RA, SLE ... Joint #Pain #MSK #rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... is rare in DIL, SCLE-DIL ... Discontinuation of causal ... drug +++, Hydroxychloroquine ... #DIL #rheumatology
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