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management hemeonc leukemia algorithm anemia aplastic chronic lymphocytic myelodysplastic syndrome blood cancer differential differentiation disorders emergencies et hemophagocytic hlh lymphohistiocytosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... night sweats, bleeding ... • Significant bleeding ... #Leukemia #Hematology ... #Oncology #Diagnosis
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Acute • Myloid (AML ... • Lymphoid (CLL ... Polycythemia Vera (PV), Essential ... - Amy Chung, MD ... Blood #Disorders #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Allogeneic stem cell ... only curative treatment ... Myelodysplastic #Syndrome #MDS ... #treatment #hematology ... #oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome in APML ... Triggers: ATRA treatment ... • Induce blast cell ... Renal Failure Treatment ... #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... microglobulin Treatment ... Transform to DLBCL, PML ... #workup #oncology ... #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
neutropenia • Mucosal bleeding ... Symptomatic anemia Diagnosis ... Consider stem cell ... Can progress to MDS ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... Lauren Banaszak, MD ... uw_IMresidency #CLL ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
unusual bruising or bleeding ... are caused by bleeding ... factor (GCSF) treatments ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
Essential Thrombocythemia ... PV, MDS, CML) Treatment ... or AML ... Thrombocythemia #ET #hematology ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
ecchymoses, mucosal bleeding ... Hypocellular/Hypoplastic MDS ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... #hematology #diagnosis
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