21 results
diagnosis differential oncology causes classification algorithm hemolytic leukemia management workup atlas hypertension lymphocytic morphology phtn pulmonary rbc agglutinin bloodcell calculation
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... ) (e.g. lupus, CLL ... lymphoproliferative disorders ... differential #diagnosis #hematology ... #anemia
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Chronic disease ... Unstable hemoglobin disorders ... : Cold autoimmune ... hemolytic anemia ... differential #diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... anemia • Cold ... malignancies -> CLL ... #hemolytic #anemia ... #hematology #diagnosis
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
of Chronic Disease ... 80-100 fL) • Bleeding ... • Hemolysis ... of Chronic Disease ... Algorithm #Causes #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... Agglutination - Cold ... Consider RBC membrane disorder ... Algorithm #workup #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... extramedullary disease ... (Chronic Myeloid ... - infiltrates (anemia ... #Leukemia #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... spherocytosis, Hemolytic ... , Bleeding gastric ... Schistocytes - Hemolytic ... #differential #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... iron deficiency, hemolysis ... inflammatory disorders ... myeloid leukemia (CML ... Diagnosis #Causes #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
kidney disease, ... Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... defects (e.g. sickle cell ... Production #Index #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Autoimmune: Warm AIHA, Cold ... Defects: Sickle cell ... anemia, Thalassemias ... Differential #Diagnosis #hematology
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