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diagnosis differential oncology algorithm management thrombocytosis classification lymphocytic workup aplastic approach atlas basophilia basophils bloodcell cancer common cvid gap globulin
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... Chronic leukemia ... -> AML: Blast crises ... - infiltrates (anemia ... #Hematology #Oncology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Blood Disorders ... - CD7, CD3 Chronic ... Pelger-Huet, Macrocytic anemia ... • Lymphoid (CLL ... #Disorders #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Myelogenous Leukemia ... • Rheumatic disorders ... Iron deficiency anemia ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... inflammatory disorders ... myeloid leukemia ... (CML) - Dr. ... #hematology #secondary
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Reactive: • Anemia ... /blood loss (Fe ... Myelofibrosis • Chronic ... Myeloid Leukemia ... #Platelets #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
lymphoproliferative disorders ... Lymphocytosis: Absolute blood ... • Neutropenia, anemia ... leukemia #CLL ... workup #oncology #hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
the total white blood ... Myeloproliferative Disorders ... : • Chronic myeloid ... leukemia (CML) ... #hematology #basophils
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- History of bleeding ... plateletcount), peripheral blood ... changes), high MCV anemia ... not required in all ... #Workup #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Diagnosis Algorithm Blood ... RBCs on Smear • Chronic ... • Anemia of Chronic ... Diagnosis #Algorithm #Causes ... #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... , Chronic disease ... disease, McLeod blood ... Unstable hemoglobin disorders ... differential #diagnosis #hematology
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