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Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Systemic Lupus (SLE ... Photosensitivity, Butterfly ... Thrombocytopenia #Lupus #SLE
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... patchy eruption - Butterfly ... lymphoproliferative syndrome Clinical ... : Drug induced SLE
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
are bilobed ("butterfly ... I see all of these ... Pathology #Hematology #Clinical
Joint Disorders - Differential Diagnosis Algorithm Monoarthritis • Septic • Crystalline - Gout
Erythematosus (SLE ... symptoms like “butterfly
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... skin -> Malar (butterfly ... Phenomenon #Lupus #SLE
Clinical Manifestations of Systemic Lupus Erythematosus (SLE) #Systemic #Lupus #Erythematosus #SLE #Manifestations #Signs #Symptoms #Rheumatology #Diagnosis
Clinical Manifestations ... Erythematosus (SLE ... Erythematosus #SLE
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Highly specific for SLE ... Association with both SLE ... is clinically suspected ... higly specific for SLE ... patients with typical SLE
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Spondyloarthropathies, SLE ... retinal exudates) - SLE ... nodules - RA, SLE ... disease - RA - SLE ... • Seizures - SLE
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus vs SLE ... to 1:1 F:M • Clinical ... 40, F:M 9:1 • Clinical ... are evocative of SLE ... management of SLE
Imaging Patterns of Toxic and Metabolic Brain Disorders Thalami, Mammillary Bodies and Tectum: Wernicke Encephalopathy Dentate Nuclei: Metronidazole,
Striatopathy "Butterfly ... Brain #Disorders #Clinical
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