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differential leukemia management liver lymphocytic thrombocytosis aclf basophilia basophils cancer classification diffuse failure gap globulin hemeonc hepatitis hodgkins injury lad
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Infectious: • Acute ... disorders • Celiac disease ... effect following treatment ... #Algorithm #Causes ... #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... can indicate disease ... ’s lymphoma or acute ... #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CLL Acute leukemias ... ALL (Acute Lymphoblastic ... extramedullary disease ... #Leukemia #Hematology ... #Oncology #Diagnosis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Failure (ACLF) Clinical ... in those with CLD ... months without treatment ... #Hepatology #gastroenterology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... , Celiac disease ... • Infections: Chronic ... #Algorithm #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Fatigue • Acute ... Age > 50 • Chronic ... Reed-Sternberg Cells ... #Algorithm #Causes ... #Hematology #Oncology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
total white blood cell ... Disorders: • Chronic ... Colitis and Crohn’s Disease ... Irradiation • Cirrhosis ... #causes #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... immunophenotype Clinical ... Transformation to large cell ... uw_IMresidency #CLL ... #hematology #hemeonc
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Causes of Acute ... breast CA, small cell ... fibrosis, Sickle cell ... hepatitis: < 1 • Cirrhosis ... #algorithm #hepatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Marrow Failure • Chronic ... Myeloproliferative Disease ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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