1167 results
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
mutated in one cell ... mutated in all cells ... Retinoblastoma Signs / Symptoms ... ophthalmology #diagnosis ... #signs #symptoms
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
- B symptoms ... Nodal disease: B symptoms ... Differential Diagnosis ... of B-Symptoms ... comparison #oncology #diagnosis
Features of a Sickle Cell Crisis 
Sickle-cell disease - an autosomal recessive blood disorder.
Characterized by red
Features of a Sickle Cell ... Crisis Sickle-cell ... These cells can ... Sickle cell disease ... Features #Signs #Symptoms
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... Reed-Sternberg (RS) Cells ... pattern of spread, B symptoms ... ~10% - B-Cell ... pathophysiology #Hematology #Diagnosis
Investigating DVT: approach to symptoms suggestive of lower limb deep vein thrombosis
#Diagnosis #DVT #deepvein #thrombosis #wells
DVT: approach to symptoms ... vein thrombosis #Diagnosis ... deepvein #thrombosis #wells ... assessment #evaluation #symptoms
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... chronic onset of symptoms ... lineage ALL Symptoms ... thrombocytosis) CML Symptoms ... Hematology #Oncology #Diagnosis
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
B and CD-4+ T cells ... CRP Neuronal cell ... surface targeted -> Cell ... pathophysiology #diagnosis ... #signs #symptoms
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
Giant Cell (Temporal ... old; F>M Signs/Symptoms ... Anemia - Giant cells ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
antibodies bind to mast cells ... activation and cell ... natural killer cells ... - Red blood cell ... Pathophysiology #Allergy #Diagnosis
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
- Differential Diagnosis ... malignancy: • Symptoms ... : B-symptoms, bruising ... predominant immature cells ... #Differential #Diagnosis