1301 results
Antibiotics and CNS Diffusion

1. Drugs with good CNS diffusion:

- Fluoroquinolones, Fluconazole, voriconazole, Rifampin, Oxazolidinones, Metronidazole

2. Drugs
Antibiotics and CNS ... Drugs with good CNS ... with moderate CNS ... Drugs with low CNS ... Perfusion #CSF #Pharmacology
Common toxicities of antifungal agents. 
CNS = central nervous system; 5-FC = flucytosine; GI = gastrointestinal;
CNS = central nervous ... SideEffects #Adverse #Pharmacology
IDSA Aspergillosis Treatment
 • Invasive pulmonary aspergillosis (IPA)
 • CNS aspergillosis
 • Cardiac Aspergillus infection
 •
aspergillosis (IPA) • CNS ... Treatment #management #pharmacology
CNS Penetration of Common ICU Antibiotics

by Dr. Megan Barra @MeganRx1

#CNS #Penetration #Antibiotics #pharmacology
CNS Penetration ... Barra @MeganRx1 #CNS ... #Antibiotics #pharmacology
Sedative-Hypnotic Drugs
Benzodiazepines:
 - Bind to specific GABAA receptor subunits at central nervous system (CNS) neuronal synapses
nervous system (CNS ... effects on the CNS ... effects on the CNS ... nuclei in the CNS ... #medications #pharmacology
Central Nervous System Pharmacology - Somatic and Autonomic Receptors
Somatic
 • Rocuronium -> Non-depolarizing (reversible competitive inhibitors)
Nervous System Pharmacology ... NervousSystem #CNS ... Autonomic #Receptors #Pharmacology
Effects of H1 Antihistamines at Histamine, Adrenergic, Cholinergic, and Serotonin-Binding Receptors
Cholinergic - Incr Dry mouth, Incr
Neurotransmission in the CNS ... Antihistamines #Pharmacology
Benzodiazepines: Mechanism of Action and Side Effects
 • Decr spinal cord activity -> Muscle relaxant
co-ingestion with other CNS ... Benzodiazepines #Psychiatry #Pharmacology
Gamma hydroxybutyrate (GHB) - Toxicology

Clinical presentation
 - Symptoms of GHB toxicity include: short term anterograde amnesia,
- Symptoms of CNS ... CNS depression will ... Diagnosis #Management #Pharmacology
Antifungal Azoles - Antibiotics Class Overview

Mechanism:  inhibit ergosterol synthesis (important component of fungal cell membranes)
Itraconazole has poor CNS ... Isavuconazole(PO or IV) #Pharmacology