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neurology clinical diagnosis physicalexam video ophthalmology differential nystagmus rheumatology causes management algorithm syndrome disease gravis myasthenia renal cnvi kidney opsoclonus
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis and Vasculitides ... pulmonary disease, and ocular ... ulcers, cutaneous, ocular ... Syndrome: - Ocular ... against MPO • Complement
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Hypocomplementemic Urticarial Vasculitis ... Complex Formation - Complement ... Formation -> Vasculitis ... Hypocomplementemic #Urticarial #Vasculitis
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
ANCA Associated Vasculitis ... anti-GBM) 10%: - Low Complement ... Syndrome, Rheumatoid Vasculitis ... - Normal Complement ... Renal Crisis, IgA Vasculitis
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
staining (lg + complement ... MGPN • Complement ... of alternative complement ... MPGN without complement ... Glomerulonephritis #MPGN #nephrology
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
ANCA-Associated Vasculitis ... , small-vessel vasculitis ... Complement levels ... Levamisole-induced vasculitis ... ANCA #Associated #Vasculitis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis
Pathogenesis of ANCA-associated vasculitis Dr. Muner Mohamed @MunerMohamed1 #ANCA #vasculitis #pathophysiology #nephrology
ANCA-associated vasculitis ... MunerMohamed1 #ANCA #vasculitis ... pathophysiology #nephrology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Vasculitis Involving ... 50% Cutaneous Vasculitis ... Leukocytoclastic Vasculitis ... SLE, RA related vasculitis ... IgM deposits • Nodular
Physical exam findings of various ocular palsies; image courtesy of the BMJ R 3rd nerve palsy R 4th
findings of various ocular ... nerve palsy #Ocular ... CNIII #CNIV #CNVI #Neurology
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
IgA Vasculitis – ... Activation of complement ... Leukocytoclastic vasculitis ... Cutaneous small vessel vasculitis ... #HSP #IgA #Vasculitis
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