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diagnosis tls tumor hematology neurology barre guillain hemeonc algorithm apml ascorbicacid criticalcare differential differentiation emergencies encephalopathy foamed gbs guillainbarre hemophagocytic
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... malignancies Treatments ... Walid Malki, MD, MS ... #Syndrome #TLS ... #oncology #management
Tumor Lysis Syndrome - Workup and Management Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... - Workup and Management ... of the above Treatment ... #Syndrome #diagnosis ... #management #oncology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
: • Pathophysiology ... have fever - ACS ... organ damage • Treatment ... Syndrome: • Pathophysiology ... #diagnosis #management
Tumor Lysis Syndrome (TLS) Pathophysiology Culprits: ALL, Burkitt, SCLC Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... #Syndrome #TLS ... #Pathophysiology ... #oncology
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
Classification of Tumor Lysis ... Syndrome (TLS) ... #TumorLysis #Syndrome ... TLS #diagnosis #management ... #oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... Pathophysiology ... APML #diagnosis #management ... #hematology #oncology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... TLS (tumor-lysis ... → no immediate treatment ... : - Seen with AML ... (~20 %) and APL
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
Guillain-Barre Pathophysiology ... complete paralysis of all ... Treatment: • Plasmapheresis ... #diagnosis #management ... #treatment #neurology
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
Diagnosis and Management ... beta-spectrin, which is crucial ... nonimmune hemolysis MSK ... vasculitis Treatment ... #AscorbicAcid #Pathophysiology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Etiology: • Pathophysiology ... circulation: MCA ACA ... epilepticus Treatment ... underlying cause • Treatment ... #diagnosis #management
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