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diagnosis hepatology transaminitis algorithm hepatitis causes chemistry cholestatic dermatology dili distribution drug enzymes gastroenterology hyperferritinemia idiosyncratic induced interpretation management patterns
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... Injury Hepatocellular ... Liver Injury ... Transaminitis #diagnosis #differential ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury - Differential ... Injury → liver ... Liver Injury Differential ... #Liver #Injury
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic - less common ... Chronic - ongoing ↑ LFTs ... Calculate R-Value • Hepatocellular ... #differential # ... gastroenterology #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... disease: > 2 • NASH ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... normal - Hemolysis, NASH ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
is made in the liver ... Most Common Causes ... Hepatocellular injury ... Hepatocellular Injury ... Hematologic Malignancy
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Acute Liver Injury ... disease: > 2 • NASH ... #differential #
Common Dermatological Conditions - Distribution and Morphology • Acne vulgaris - Face, upper back, chest -
Common Dermatological ... site of previous injury ... Trunk, especially anterior ... #rash #differential ... diagnosis #skin #common
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