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rheumatology differential erythematosus lupus systemic syndrome vasculitis ana antibodies antinuclear autoantibodies autoimmune classification management mimickers pathophysiology patterns vasculitides
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
Primary Sjogren’ ... biliary cirrhosis ... erythematosus (SLE ... ) Signs / Symptoms ... #Signs #Symptoms
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Photosensitivity, Butterfly rash ... Glomerulonephritis Myositis ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
less systemic symptoms ... can present with rash ... , Shaw sign, holster ... Can also see mechanics ... #diagnosis #rheumatology
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
Erythematosus (SLE ... ) - Typical Signs ... Arthralgia / arthritis, Myositis ... #Signs #Symptoms ... #diagnosis #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... Syndrome, Myositis ... Autoimmune Hepatitis, Primary ... Biliary Cirrhosis ... #diagnosis #differential
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
69% - Malar rash ... anemia 4% - Myositis ... Lupusreference #SLE ... autoantibodies #signs ... #symptoms #mimickers
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... overlaps with RA, SLE ... neuropathy, transverse myelitis ... biliary cirrhosis ... Nephrogenic DI Hematologic
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... dermatomyositis, Sjogren ... Malignancy (e.g. hematologic ... the context of primary ... Induced Lupus: • Symptoms
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... purpura: Strong sign ... with GCA or as primary ... • Rash, arthritis ... Primary Angiitis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Rash, arthritis ... Presentation - Systemic Symptoms ... purpura: strong sign ... vasculitis, and SLE ... #rheumatology #
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