264 results
Expected DAT Results in Autoimmune Hemolysis
DAT Negative Hemolysis
 • DAT Poly ( - ), IgG (
Expected DAT Results ... in Autoimmune Hemolysis ... • DAT Poly ( ... - ) WAIHA • DAT ... #Autoimmune #Hemolysis
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Autoimmune Hemolytic ... IgG mediated - DAT ... IgM mediated - DAT ... BrighamMedRes #AIHA #Autoimmune
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
blood smear + DAT ... Heinz bodies, DAT ... Sickle cells, DAT ... • Spherocytes, DAT ... idiopathic, malignancy, autoimmune
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Mixed-type AIHA (7-8%) DAT-negative ... MatthewHoMD #Autoimmune
Causes of Leukocytosis and Leukopenia - Differential Diagnosis
 • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
Infection, Malignancy, Autimmune ... Lymphocytopenia: Infections, Autoimmune ... Infections, Drugs, Autoimmune ... Infection, Malignancy, Autoimmune
Causes of Adrenal Insufficiency - Differential Diagnosis Algorithm
Autoimmune:
 • Isolated
 • Polyglandular autoimmune syndrome 1
 •
Diagnosis Algorithm Autoimmune ... Polyglandular autoimmune ... Polyglandular autoimrnune
Hemolysis Classification - Intrinsic and Extrinsic Causes

Commentary: Another way to think of immune hemolysis would be
hemolysis would be autoimmune ... already listed) and alloimmune
Causes of Hemolytic Anemia - Differential Diagnosis
Inherited
 • Membrane
 • Internal
    - Hemoglobin
- Antibody/DAT ... - Complement/DAT
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolysis: • Autoimmune ... Anemias (AIHAs) • Alloimmune
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
methotrexate) • Drugs Autoimmune ... CLL • APLA Alloimmune