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diagnosis rheumatology differential management oncology classification dermatology erythematosus systemic algorithm arthritis druginduced hemophagocytic hlh leukemia lymphohistiocytosis mds msk myelodysplastic summary
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
• Immunologic Workup ... Positive in 60-80% of cases ... life-threatening • Treatment ... • Evolution: ... Chronic disease
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... • Immunologic Workup ... life-threatening • Treatment ... Chronic disease ... #table #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgG) (e.g. lupus ... Hemoglobinopathies (e.g. sickle cell ... differential #diagnosis #hematology ... #anemia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
can indicate disease ... • Neutropenia, anemia ... microglobulin Treatment ... ’s lymphoma or acute ... #oncology #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... test, ANA (e.g., SLE ... changes), high MCV anemia ... - Bone marrow evaluation ... #Workup #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... formed or don’t work ... Myeloproliferative Disease ... Workup: • Complete ... #diagnosis #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute ... #hematology #oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Classification: • Acute ... Angioimmunoblastic T-cell ... lymphopenia, low PLT • Anemia ... : • Chronic B-cell
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Vasculitides: Giant Cell ... arteritis, Cogan's Syndrome ... (RA), Systemic lupus ... erythematosus (SLE ... Differential #Diagnosis #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Demyelinating Syndrome ... Cerebrovascular Disease ... autoantibodies that will cause ... Erythematosus #SLE
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